Dimethylformamide → Benzoyl chloride, 3-nitro-

HRID 323785Notes

Reaction equation

HRID 323785 reaction equation
[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7](O)=[O:8])([O-:3])=[O:2].C(Cl)(=O)C([Cl:16])=O.CN(C=O)C>C1C=CC=CC=1>[N+:1]([C:4]1[CH:5]=[C:6]([CH:10]=[CH:11][CH:12]=1)[C:7]([Cl:16])=[O:8])([O-:3])=[O:2]

Participants

5

Reactant 3

HCID 6228DimethylformamideHCID 84973-Nitrobenzoic acidHCID 65578Oxalyl chloride

Product 1

HCID 8495Benzoyl chloride, 3-nitro-

Reagents, catalysts & solvents 1

HCID 241BenzeneSolvent

Procedure

To a suspension of 3-nitrobenzoic acid (934 mg, 5.64 mmol) in benzene (15 mL) was added oxalyl chloride (0.6 mL, 6.77 mmol) and DMF (7 mL), respectively. The resulting mixture was stirred at room temperature until a clear solution was formed. The solvent was removed under reduced pressure and crude acid chloride was used in the next reaction without further purification.

Workup

  1. customwas formed
  2. customThe solvent was removed under reduced pressure and crude acid chloride
  3. customwas used in the next reaction without further purification

Sources & evidence

ORD record
ord-7fb1dfcc9dc246649d812e1142a16729
Source dataset
uspto-grants-2001_04
Patent number
US06214881B1

Reaction notes

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