Methanesulfonic Acid → HCID 88219091, compound

HRID 323792Notes

Reaction equation

HRID 323792 reaction equation
[NH2:1][CH2:2][CH:3]([C:5]1[CH:10]=[C:9]([S:11](=[O:14])(=[O:13])[NH2:12])[CH:8]=[CH:7][C:6]=1[O:15][CH3:16])[OH:4].[CH3:17][S:18](O)(=[O:20])=[O:19]>CO>[CH3:17][S:18]([O:4][CH:3]([CH2:2][NH2:1])[C:5]1[CH:10]=[C:9]([S:11](=[O:13])(=[O:14])[NH2:12])[CH:8]=[CH:7][C:6]=1[O:15][CH3:16])(=[O:20])=[O:19]

Participants

4

Reactant 2

HCID 6395Methanesulfonic AcidHCID 99060413-(2-Amino-1-hydroxyethyl)-4-methoxybenzene-1-sulfonamide

Product 1

HCID 88219091HCID 88219091, compound

Reagents, catalysts & solvents 1

HCID 887MethanolSolvent

Procedure

Starting from (+)-α-aminomethyl-2-methoxy-5-sulphamoylbenzenemethanol treated with 1 equivalent of methanesulphonic acid in 2M solution in methanol, recrystallization in methanol and diethyl ether and drying in a desiccator under vacuum over phosphorus pentoxide, (+)-α-aminomethyl-2-methoxy-5-sulphamoylbenzenemethanol methanesulphonate was obtained.

Workup

  1. customrecrystallization in methanol
  2. dry with materialdiethyl ether and drying in a desiccator under vacuum over phosphorus pentoxide

Sources & evidence

ORD record
ord-e57b92a097924e2dbdb6a4c368df5158
Source dataset
uspto-grants-2001_04
Patent number
US06214882B1

Reaction notes

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