反应详情

温度

80 °C

180 g (1 mol) of 3-ethylxanthine were initially introduced into 1000 ml of dimethylformamide, the mixture was heated to 80° C. with stirring and, after the introduction of 88 g (0.64 mol) of potassium carbonate, treated dropwise with 133 g (1.05 mol) of benzyl chloride in the course of 1 hour. It was then stirred at 100° C. for 2 hours, treated with 1000 ml of water, and the precipitated product was filtered on a suction filter, washed with water until salt-free and dried in a vacuum drying oven at 100° C. If necessary, a further purification can be carried out by reprecipitating from 1 N sodium hydroxide solution using 4 N hydrochloric acid analogously to Example 1a).

1. stirringIt was then stirred at 100° C. for 2 hours
2. filtrationthe precipitated product was filtered on a suction
3. filtrationfilter
4. washwashed with water until salt-free and
5. customdried in a vacuum
6. customdrying oven at 100° C
7. customIf necessary, a further purification
8. customby reprecipitating from 1 N sodium hydroxide solution