反应详情

温度

47.5 °C

Into 700 ml ethyl acetate at 0-10° C. 109.8 g (3 mol) of hydrogen chloride gas was introduced and to the solution 83 g (0.3 mol) of the [2-(2-thienyl)ethylamino](2-chorophenyl)acetonitrile of formula (I), prepared according to Example 1. or 2., and 15 ml (0.37 mol) of methanol are added and the mixture is slowly, in a period of 20 minutes, heated to 45-50° C. The reaction mixture is then stirred at 45-50° C. for 4 hours, the crystalline product is filtered off at room temperature, washed with ethyl acetate and dried. Weight: 90.4 g (91%) op.: 231-232° C. The quality of the product is identical with that of the product of Example 5.

1. customat 0-10° C
2. customprepared
3. filtrationthe crystalline product is filtered off at room temperature
4. washwashed with ethyl acetate
5. customdried
6. custom231-232° C