反应详情

Thionyl chloride (10 ml) was added to 4-morpholinepropane sulfonic acid (4.4 g) followed by dimethylformamide (0.2 ml). The mixture was heated at reflux under nitrogen for 5 h. The thionyl chloride was removed in vacuo and the residue triturated with acetonitrile and filtered to give a white solid. This was dried at 80° C. in vacuo to give the title compound as a white solid (2.7 g). Found: C,31.9; H,5.9; N,5.1. C7H14CINO3S.HCl requires C,31.8; H,5.7; N,5.3%.

1. temperatureThe mixture was heated
2. temperatureat reflux under nitrogen for 5 h
3. customThe thionyl chloride was removed in vacuo
4. customthe residue triturated with acetonitrile
5. filtrationfiltered
6. customto give a white solid
7. customThis was dried at 80° C. in vacuo