Propane sultone → HCID 22007665, compound

HRID 324000Notes

Reaction equation

HRID 324000 reaction equation
[CH3:1][N:2]1[CH2:7][CH2:6][NH:5][CH2:4][CH2:3]1.[CH2:8]1[CH2:14][S:11](=[O:13])(=[O:12])[O:10][CH2:9]1>C(O)(C)C.CCOCC>[CH3:1][N:2]1[CH2:7][CH2:6][N:5]([CH2:9][CH2:8][CH2:14][S:11]([OH:13])(=[O:12])=[O:10])[CH2:4][CH2:3]1

Participants

5

Reactant 2

HCID 14264Propane sultoneHCID 531671-Methylpiperazine

Product 1

HCID 22007665HCID 22007665, compound

Reagents, catalysts & solvents 2

HCID 3283Diethyl EtherSolventHCID 3776IsopropanolSolvent

Procedure

N-methyl piperizine (4.68 g) was dissolved in isopropanol (25 ml) and treated with 1,3-propanesultone (5.7 g) with cooling to maintain the temperature of the reaction below 50° C. The reaction mixture was allowed to stand at room temperature overnight, then diluted with ether and the white solid filtered. On standing, the white solid became a sticky semi-solid (7.1 g). Mass spec MH+ (found)=223 MH+ (calc)=223.

Workup

  1. temperaturewith cooling
  2. temperatureto maintain
  3. customthe temperature of the reaction below 50° C
  4. filtrationthe white solid filtered

Sources & evidence

ORD record
ord-5e4e3ccfeec44247a09ad49d73d90318
Source dataset
uspto-grants-2001_04
Patent number
US06215002B1

Reaction notes

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