Morpholine → MOBS

HRID 324001Notes

Reaction equation

HRID 324001 reaction equation
[NH:1]1[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1.[CH2:7]1[CH2:14][O:13][S:10](=[O:12])(=[O:11])[CH2:9][CH2:8]1>C(O)(C)C>[N:1]1([CH2:14][CH2:7][CH2:8][CH2:9][S:10]([OH:13])(=[O:12])=[O:11])[CH2:6][CH2:5][O:4][CH2:3][CH2:2]1

Participants

4

Reactant 2

HCID 8083MorpholineHCID 154111,4-Butane sultone

Product 1

HCID 3674064MOBSYield 18%

Reagents, catalysts & solvents 1

HCID 3776IsopropanolSolvent

Procedure

Morpholine (3.56 g) was dissolved in isopropanol (25 ml) and treated with 1,4-butane sultone (5.58 g) at 10° C. The reaction mixture was allowed to warm to room temperature and stirred for 3 days. The white precipitate that had formed was filtered and dried to give the title compound (1.64 g). Mass spec MH+ (found) 224 MH+ (calc) 224.

Workup

  1. customThe white precipitate that had formed
  2. filtrationwas filtered
  3. customdried

Sources & evidence

ORD record
ord-046aeab13c1c457f8b2a1d4d244bc5bc
Source dataset
uspto-grants-2001_04
Patent number
US06215002B1

Reaction notes

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