反应详情

To a mixture of 1.6 grams of citric acid monohydrate, 0.6 grams of sodium citrate dihydrate and 40 grams of SBE-CD in a volumetric flask was added with stirring at room temperature 170 mL of deionized water. The mixture was stirred for 30 minutes with frequent sonication until a clear solution was obtained. There was added to the solution 4.0 grams of compound I. The mixture was stirred additionally for 2 hours until a clear solution was obtained. After that, the volume of the solution was adjusted to 200 mL with deionized water and the resulting solution was thoroughly mixed and filtered through a 0.22 μm filter. The clear filtrate contained the complex of 20 mg/mL of compound I (free base equivalent) in 20% w/v SBE-CD solution.

1. additionwas added
2. customwas obtained
3. stirringThe mixture was stirred additionally for 2 hours until a clear solution
4. customwas obtained
5. additionthe resulting solution was thoroughly mixed
6. filtrationfiltered through a 0.22 μm
7. filtrationfilter