Hydrochloric Acid → HCID 22004359, compound

HRID 324341Notes

Reaction equation

HRID 324341 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:7](=O)[O:6][C:5]2=[CH:12][C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1.O.[NH2:20][NH2:21].O.Cl>C(O)C>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[C:7](=[O:6])[NH:21][N:20]=[C:5]2[CH2:12][C:13]1[CH:14]=[N:15][CH:16]=[CH:17][CH:18]=1

Participants

6

Reactant 4

HCID 313Hydrochloric AcidHCID 962WaterHCID 24654Hydrazine hydrate (1:1)HCID 54459068HCID 54459068, compound

Product 1

HCID 22004359HCID 22004359, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

5-Chloro-3-(pyrid-3-yl)methylenephthalide (2.68 g) was dissolved in 100 ml of ethanol, followed by the addition of 2.0 ml of hydrazine monohydrate. The obtained mixture was heated under reflux for 4 hours, followed by the addition of 200 ml of water. The resulting mixture was neutralized with dilute hydrochloric acid to precipitate crystals, which were recovered by filtration to give 1.87 g of the title compound as a yellow powder.

Workup

  1. temperatureThe obtained mixture was heated
  2. temperatureunder reflux for 4 hours
  3. customto precipitate crystals, which
  4. filtrationwere recovered by filtration

Sources & evidence

ORD record
ord-5dcf225965f842dcbfd44dfe4e87c6c8
Source dataset
uspto-grants-2001_04
Patent number
US06218392B1

Reaction notes

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