反应详情

A mixture of 5-chloro-1H-indole (25 g), piperidin-4-one, hydrate, hydrochloride (71 g), and potassium hydroxide (38 g) in ethanol (450 ml) was refluxed for 6 hours. After cooling inorganic salts were filtered off and ethanol evaporated in vacuo. To the remaining oil was added brine (500 ml) and ethyl acetate (2×200 ml). The organic phase was separated and worked-up as above. Yield of crude title product: 45 g (semicrystalline).

1. temperaturewas refluxed for 6 hours
2. temperatureAfter cooling inorganic salts
3. filtrationwere filtered off
4. customethanol evaporated in vacuo
5. additionTo the remaining oil was added brine (500 ml) and ethyl acetate (2×200 ml)
6. customThe organic phase was separated