反应详情

To a solution of potassium tert-butoxide (67.5 g) in tetrahydrofuran (500 ml) was added 5-bromo-2,4-dichloropyrimidine (55 g) (J. Am. Chem. Soc., 1934, 56, 134) in tetrahydrofuran (100 ml) dropwise. After 1.5 hours water (100 ml) was added carefully and the mixture extracted with ethyl acetate. The combined organic solution was washed with water, dried (MgSO4) and evaporated under reduced pressure. Purification was by chromatography eluting with isohexane containing 1% triethylamine.

1. extractionthe mixture extracted with ethyl acetate
2. washThe combined organic solution was washed with water
3. dry with materialdried (MgSO4)
4. customevaporated under reduced pressure
5. customPurification
6. washeluting with isohexane containing 1% triethylamine