Sodium Hydroxide → HCID 22003631, compound

HRID 324487Notes

Reaction equation

HRID 324487 reaction equation
[Cl:1][C:2]1[S:3][C:4]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=2)=[C:5]([C:7]([O:9]C)=[O:8])[N:6]=1.[OH-].[Na+]>O1CCCC1.O>[Cl:1][C:2]1[S:3][C:4]([CH2:11][CH2:12][C:13]2[CH:18]=[CH:17][CH:16]=[C:15]([Cl:19])[CH:14]=2)=[C:5]([C:7]([OH:9])=[O:8])[N:6]=1

Participants

5

Reactant 2

HCID 14798Sodium HydroxideHCID 131722527HCID 131722527, compound

Product 1

HCID 22003631HCID 22003631, compound

Reagents, catalysts & solvents 2

HCID 962WaterSolventHCID 8028TetrahydrofuranSolvent

Procedure

The product from step (ii) (3.46 g) was treated with sodium hydroxide (0.7 g) in tetrahydrofuran (15 ml) and water (15 m) at room temperature. After 3 h the mixture was partitioned between 2M HCl and ethyl acetate. The organic phase was collected, dried (MgSO4) and solvent evaporated under reduced pressure to leave a colourless solid.

Workup

  1. customAfter 3 h the mixture was partitioned between 2M HCl and ethyl acetate
  2. customThe organic phase was collected
  3. dry with materialdried (MgSO4) and solvent
  4. customevaporated under reduced pressure
  5. customto leave a colourless solid

Sources & evidence

ORD record
ord-1fe122ffc1ad43009bd4d4e2c052f5d7
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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