Pyrrolidine → HCID 70115681, compound

HRID 324497Notes

Reaction equation

HRID 324497 reaction equation
Cl[C:2]1[S:3][C:4]2[CH:11]=[CH:10][C:9]3[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:8]=3[CH:7]([C:17]3[C:18](=[O:25])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:5]=2[N:6]=1.[NH:26]1[CH2:30][CH2:29][CH2:28][CH2:27]1>O1CCOCC1>[Cl:16][C:13]1[CH:14]=[CH:15][C:8]2[CH:7]([C:17]3[C:18](=[O:25])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:5]3[N:6]=[C:2]([N:26]4[CH2:30][CH2:29][CH2:28][CH2:27]4)[S:3][C:4]=3[CH:11]=[CH:10][C:9]=2[CH:12]=1

Participants

4

Reactant 2

HCID 31268PyrrolidineHCID 70113243(+/-)-5-(2,7-Dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 70115681HCID 70115681, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

The product from example 44 step (viii) (0.042 g) was treated with pyrrolidine (0.1 ml) in 1,4-dioxane (3 ml) at reflux for 6 h. The volatiles were removed under reduced pressure and the residue triturated with diethyl ether/isohexane mixtures to leave the subtitle product as a pale yellow solid.

Workup

  1. temperatureat reflux for 6 h
  2. customThe volatiles were removed under reduced pressure
  3. customthe residue triturated with diethyl ether/isohexane mixtures

Sources & evidence

ORD record
ord-978a362d491b45879a3b04ed7da81e0c
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

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