2-Morpholinoethylamine → HCID 88151425, compound

HRID 324499Notes

Reaction equation

HRID 324499 reaction equation
Cl[C:2]1[S:3][C:4]2[CH:11]=[CH:10][C:9]3[CH:12]=[C:13]([Cl:16])[CH:14]=[CH:15][C:8]=3[CH:7]([C:17]3[C:18](=[O:25])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:5]=2[N:6]=1.[NH2:26][CH2:27][CH2:28][N:29]1[CH2:34][CH2:33][O:32][CH2:31][CH2:30]1>>[Cl:16][C:13]1[CH:14]=[CH:15][C:8]2[CH:7]([C:17]3[C:18](=[O:25])[NH:19][C:20](=[O:24])[N:21]([CH3:23])[CH:22]=3)[C:5]3[N:6]=[C:2]([NH:26][CH2:27][CH2:28][N:29]4[CH2:34][CH2:33][O:32][CH2:31][CH2:30]4)[S:3][C:4]=3[CH:11]=[CH:10][C:9]=2[CH:12]=1

Participants

3

Reactant 2

HCID 4082852-MorpholinoethylamineHCID 70113243(+/-)-5-(2,7-Dichloro-4H-benzo[5,6]cyclohepta[1,2-d]thiazol-4-yl)-1-methyl-2,4(1H,3H)-pyrimidinedione

Product 1

HCID 88151425HCID 88151425, compound

Procedure

The subtitle product was prepared from the product of example 44 step (viii) (0.225 g) and 4-(2-aminoethyl)morpholine (0.38 ml) according to the method of example 51 step (i). Purification was by precipitation using diethyl ether with filtration to give the subtitle product as yellow solid.

Workup

  1. customPurification
  2. customwas by precipitation
  3. filtrationwith filtration

Sources & evidence

ORD record
ord-1d94a2d68210412eb844a7465158a732
Source dataset
uspto-grants-2001_04
Patent number
US06218376B1

Reaction notes

Loading…