反应详情

温度

80 °C

Concentrated hydrochloric acid (140μL) was added to a solution of the nitrobenzamide, V.3 (147 mg, 0.30 mmol) in methanol (2 ml). Iron (72 mg) was added and the reaction mixture was heated to 80° C. for 2 hours, before cooling. The reaction mixture was basified (saturated sodium carbonate solution), extracted into ethyl acetate, dried over magnesium sulphate and the solvent removed in vacuo to yield an off-white solid which was purified using flash chromatography(ethyl acetate) to yield the desired 2-aminobenzamide, VI.3 (47 mg, 34%).

1. temperaturebefore cooling
2. extractionextracted into ethyl acetate
3. dry with materialdried over magnesium sulphate
4. customthe solvent removed in vacuo
5. customto yield an off-white solid which
6. customwas purified