反应详情

A mixture of 3-quinolinecarboxylic acid (1.73 g, 10.0 mmol) in trifluoroacetic acid (20 ml) with platinum dioxide (200 mg) was shaken in a Parr vessel at 10-15 psi. After 90 minutes the reaction mixture was filtered and the solvent removed in vacuo to yield an oil. The oil was added dropwise onto diethyl ether yielding a white solid which was collected by filtration and then recrystallised from ethyl acetate/hexane to yield the title compound as a white solid (770 mg).

1. filtrationAfter 90 minutes the reaction mixture was filtered
2. customthe solvent removed in vacuo
3. customto yield an oil
4. additionThe oil was added dropwise onto diethyl ether yielding a white solid which
5. filtrationwas collected by filtration
6. customrecrystallised from ethyl acetate/hexane