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In a solvent mixture of 250 ml of acetic acid and 40 ml of ethyl acetate was dispersed 190 g of 1-benzylhydantoin and the mixture was refluxed under heating with stirring. To the mixture was added dropwise 164 g of bromine over a period of one hour, and the mixture was refluxed under heating for 30 minutes. The solvent was distilled off under a reduced pressure and the residue was allowed to stand for cooling. To the residue were added dropwise an aqueous sodium bicarbonate solution prepared by dissolving 53 g of sodium bicarbonate in 400 ml of water and then 200 ml of water. The reaction vessel was cooled with water and the crystals thus-deposited were collected by filtration, washed with water and dried to obtain 182 g of 5-hydroxy-1-benzylhydantoin as colorless crystals.

1. temperaturethe mixture was refluxed
2. temperatureunder heating
3. temperaturethe mixture was refluxed
4. temperatureunder heating for 30 minutes
5. distillationThe solvent was distilled off under a reduced pressure
6. temperaturefor cooling
7. additionTo the residue were added dropwise an aqueous sodium bicarbonate solution
8. customprepared
9. filtrationthe crystals thus-deposited were collected by filtration
10. washwashed with water
11. customdried