反应详情

温度

60 °C

In 10 ml of DMF, 400 mg (1.04 mmol) of Compound 43 obtained in Example 43 was dissolved, and 0.51 ml (3.6 mmol) of 2-phenylethyl bromide and 1 ml of triethylamine were added thereto, followed by stirring at 60° C. for 2 hours. The reaction mixture was extracted by adding chloroform and water, and the organic phase was dried over anhydrous magnesium sulfate. After evaporation of the solvent under reduced pressure, the residue was purified by silica gel column chromatography [chloroform-methanol (97:3)] and recrystallized from ethyl. acetate-hexane to give 369 mg (yield: 95%) of Compound 46 as light gray powder.

1. extractionThe reaction mixture was extracted
2. additionby adding chloroform and water
3. dry with materialthe organic phase was dried over anhydrous magnesium sulfate
4. customAfter evaporation of the solvent under reduced pressure
5. customthe residue was purified by silica gel column chromatography [chloroform-methanol (97:3)]
6. customrecrystallized from ethyl