Hydrochloric Acid → HCID 131721416, compound

HRID 325153Notes

Reaction equation

HRID 325153 reaction equation
[CH2:1]([S:6]([C:9]1[CH:10]=[CH:11][C:12]2[C:16]([C:17]([C:19]3[CH:24]=[CH:23][C:22]([O:25][CH2:26][CH2:27][N:28]4[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:21][CH:20]=3)=[O:18])=[C:15]([C:34]3[CH:39]=[CH:38][C:37]([S:40]([CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])(=[O:42])=[O:41])=[CH:36][CH:35]=3)[S:14][C:13]=2[CH:48]=1)(=[O:8])=[O:7])[CH2:2][CH2:3][CH2:4][CH3:5].[ClH:49]>C(OCC)(=O)C>[ClH:49].[CH2:1]([S:6]([C:9]1[CH:10]=[CH:11][C:12]2[C:16]([C:17]([C:19]3[CH:20]=[CH:21][C:22]([O:25][CH2:26][CH2:27][N:28]4[CH2:33][CH2:32][CH2:31][CH2:30][CH2:29]4)=[CH:23][CH:24]=3)=[O:18])=[C:15]([C:34]3[CH:39]=[CH:38][C:37]([S:40]([CH2:43][CH2:44][CH2:45][CH2:46][CH3:47])(=[O:42])=[O:41])=[CH:36][CH:35]=3)[S:14][C:13]=2[CH:48]=1)(=[O:8])=[O:7])[CH2:2][CH2:3][CH2:4][CH3:5]

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 18357250HCID 18357250, compound

Product 1

HCID 131721416HCID 131721416, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

[6-(n-Pentylsulfonoyl)-2-[4-(n-pentylsulfonoyl)phenyl]benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]-phenyl] methanone (3.7 g) was dissolved in 25 ml of ethyl acetate and a solution of hydrochloric acid saturated diethyl ether was added. A precipitate formed and the liquid decanted off. The gummy solid was triturated with diethyl ether and dried in vacuo at room temperature to afford 2.12 g of the title compound as a white amorphous and hygroscopic solid.

Workup

  1. customA precipitate formed
  2. customthe liquid decanted off
  3. customThe gummy solid was triturated with diethyl ether
  4. customdried in vacuo at room temperature

Sources & evidence

ORD record
ord-c9a278e3d0fa4bada6cf72122a7899ae
Source dataset
uspto-grants-2001_04
Patent number
US06221838B1

Reaction notes

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