Ether hydrochloride → HCID 22001270, compound

HRID 325157Notes

Reaction equation

HRID 325157 reaction equation
[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([C:10]([C:12]3[CH:17]=[CH:16][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:26][CH2:25][CH2:24][CH2:23][CH2:22]4)=[CH:14][CH:13]=3)=[O:11])=[C:8]([C:27]3[CH:32]=[CH:31][C:30]([S:33]([CH2:36][CH2:37][CH2:38][CH3:39])(=[O:35])=[O:34])=[CH:29][CH:28]=3)[S:7][C:6]=2[CH:40]=1.[ClH:41].C(OCC)C>C(OCC)(=O)C>[ClH:41].[OH:1][C:2]1[CH:3]=[CH:4][C:5]2[C:9]([C:10]([C:12]3[CH:13]=[CH:14][C:15]([O:18][CH2:19][CH2:20][N:21]4[CH2:22][CH2:23][CH2:24][CH2:25][CH2:26]4)=[CH:16][CH:17]=3)=[O:11])=[C:8]([C:27]3[CH:28]=[CH:29][C:30]([S:33]([CH2:36][CH2:37][CH2:38][CH3:39])(=[O:35])=[O:34])=[CH:31][CH:32]=3)[S:7][C:6]=2[CH:40]=1

Participants

4

Reactant 2

HCID 10953452Ether hydrochlorideHCID 18357241HCID 18357241, compound

Product 1

HCID 22001270HCID 22001270, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

1.7 g of [6-hydroxy-2-[4-(n-butylsulfonoyl)-phenyl]benzo[b]-thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone (2.86 mmol) was dissolved in ethyl acetate and a saturated solution of hydrogen chloride-diethyl ether was added. A thick white precipitate formed. The liquid was decanted off. The remaining solid was triturated with diethyl ether (2×) and dried to afford 1.57 g of the title compound as a white amorphous powder.

Workup

  1. customA thick white precipitate formed
  2. customThe liquid was decanted off
  3. customThe remaining solid was triturated with diethyl ether (2×)
  4. customdried

Sources & evidence

ORD record
ord-907b66cd1e36455b8e137db0175cc3b0
Source dataset
uspto-grants-2001_04
Patent number
US06221838B1

Reaction notes

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