Hydrochloric Acid → HCID 22001276, compound

HRID 325158Notes

Reaction equation

HRID 325158 reaction equation
[CH2:1]([S:5]([C:8]1[CH:9]=[CH:10][C:11]2[C:15]([C:16]([C:18]3[CH:23]=[CH:22][C:21]([O:24][CH2:25][CH2:26][N:27]4[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]4)=[CH:20][CH:19]=3)=[O:17])=[C:14]([C:33]3[CH:38]=[CH:37][C:36]([OH:39])=[CH:35][CH:34]=3)[S:13][C:12]=2[CH:40]=1)(=[O:7])=[O:6])[CH2:2][CH2:3][CH3:4].C(OCC)C.[ClH:46]>C(OCC)(=O)C>[ClH:46].[CH2:1]([S:5]([C:8]1[CH:9]=[CH:10][C:11]2[C:15]([C:16]([C:18]3[CH:19]=[CH:20][C:21]([O:24][CH2:25][CH2:26][N:27]4[CH2:32][CH2:31][CH2:30][CH2:29][CH2:28]4)=[CH:22][CH:23]=3)=[O:17])=[C:14]([C:33]3[CH:38]=[CH:37][C:36]([OH:39])=[CH:35][CH:34]=3)[S:13][C:12]=2[CH:40]=1)(=[O:7])=[O:6])[CH2:2][CH2:3][CH3:4]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 3283Diethyl EtherHCID 22001259HCID 22001259, compound

Product 1

HCID 22001276HCID 22001276, compound

Reagents, catalysts & solvents 1

HCID 8857Ethyl AcetateSolvent

Procedure

3 g of [6-n-butylsulfonoyl-2-[4-hydroxyphenyl]benzo[b]thien-3-yl]-[4-[2-(1-piperidinyl)ethoxy]phenyl]methanone was dissolved in 50 ml of ethyl acetate and a solution of diethyl ether saturated with hydrogen chloride was added. A thick white precipitate formed and the liquid was decanted off. The solid was triturated (2×) with diethyl ether and dried. This afforded 2.51 g of the title compound as a white amorphous powder.

Workup

  1. customA thick white precipitate formed
  2. customthe liquid was decanted off
  3. customThe solid was triturated (2×) with diethyl ether
  4. customdried

Sources & evidence

ORD record
ord-0ff01e3bc5a44865a19a64bdec058a4d
Source dataset
uspto-grants-2001_04
Patent number
US06221838B1

Reaction notes

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