反应详情

A stirring solution of 3.5 g. (0.014 mole) of 4-phenyl-3-methylthioindolin-2-one in 75 ml. of tetrahydrofuran was treated portionwise with 20 g. of a commercial Raney nickel/water suspension. The mixture was filtered through Celite and the filtrate was concentrated to give a yellow solid. The solid was recrystallized to give a yellow solid. This solid was recrystallized from benzene to yield 1.6 g. (57%) of product as an off-white solid. An analytical sample was prepared from isopropanol; m.p. 192-194° C.

1. filtrationThe mixture was filtered through Celite
2. concentrationthe filtrate was concentrated
3. customto give a yellow solid
4. customThe solid was recrystallized
5. customto give a yellow solid
6. customThis solid was recrystallized from benzene
7. customto yield 1.6 g