HCID 178488775, compound → 2-(3-Pyridyl)-4-(4-hydroxyphenyl)imidazole

HRID 325346Notes

Reaction equation

HRID 325346 reaction equation
C[O:2][C:3]1[CH:8]=[CH:7][C:6]([C:9]2[N:10]=[C:11]([C:14]3[CH:15]=[N:16][CH:17]=[CH:18][CH:19]=3)[NH:12][CH:13]=2)=[CH:5][CH:4]=1>Br>[N:16]1[CH:17]=[CH:18][CH:19]=[C:14]([C:11]2[NH:12][CH:13]=[C:9]([C:6]3[CH:7]=[CH:8][C:3]([OH:2])=[CH:4][CH:5]=3)[N:10]=2)[CH:15]=1

Participants

3

Reactant 1

HCID 178488775HCID 178488775, compound

Product 1

HCID 1785158852-(3-Pyridyl)-4-(4-hydroxyphenyl)imidazole

Reagents, catalysts & solvents 1

HCID 260Hydrogen BromideSolvent

Procedure

A mixture of 4-(p-methoxyphenyl)-2-(3-pyridyl)imidazole (2.0 g.) and 48% HBr (100 ml.) is heated to reflux for 20 hrs. After cooling, the precipitate is filtered off and crystallized from isopropanol-methanol to give 2.05 g. of 2-(3-pyridyl)-4-(4-hydroxyphenyl)imidazle of m.p. 315°-318° C.

Workup

  1. temperatureis heated
  2. temperatureto reflux for 20 hrs
  3. temperatureAfter cooling
  4. filtrationthe precipitate is filtered off
  5. customcrystallized from isopropanol-methanol
  6. customto give 2.05 g

Sources & evidence

ORD record
ord-ebe3842b9a18461ab677b21626116f6d
Source dataset
uspto-grants-1984_04
Patent number
US04440774

Reaction notes

Loading…