Methane → HCID 70491261, compound

HRID 325387Notes

Reaction equation

HRID 325387 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[CH:5][N:6]=1.O.[C:8]([OH:12])(=[O:11])[CH:9]=[O:10].[OH-].[Na+].C>>[OH2:10].[OH:10][CH:9]([C:4]1[S:3][C:2]([NH2:1])=[N:6][CH:5]=1)[C:8]([OH:12])=[O:11]

Participants

6

Reactant 5

HCID 297MethaneHCID 21552-AminothiazoleHCID 14798Sodium HydroxideHCID 15620607Glyoxylic acid, monohydrateHCID 178509095HCID 178509095, compound

Product 1

HCID 70491261HCID 70491261, compound

Procedure

A mixture of 2-amino-1,3-thiazole, which can be represented as 2-imino-2,3-dihydro-1,3-thiazole, (36.3 g.), glyoxylic acid hydrate (50 g.) and 1 N sodium hydroxide (543 ml.) was stirred for 1.5 hours at 90° to 93° C. After the reaction, the reaction mixture was treated with an activated charcoal and then adjusted to pH 3. The mixture was allowed to stand overnight under ice-cooling. The precipitates were collected by filtration, washed with water and then dried to give 2-hydroxy-2-(2-amino-1,3-thiazol-5-yl)acetic acid hydrate, which can be represented as 2-hydroxy-2-(2-imino-2,3-dihydro-1,3-thiazol-5-yl)acetic acid hydrate (48.1 g.), mp. 140° to 200° C. (dec.).

Workup

  1. customAfter the reaction
  2. waitto stand overnight under ice-
  3. temperaturecooling
  4. filtrationThe precipitates were collected by filtration
  5. washwashed with water
  6. customdried

Sources & evidence

ORD record
ord-9d7bb5b0ff4c4626bee61d9fbd1382ae
Source dataset
uspto-grants-1984_04
Patent number
US04440766

Reaction notes

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