Hydrochloric Acid → 2-Acetylthio-3-methoxybenzoic acid

HRID 325498Notes

Reaction equation

HRID 325498 reaction equation
[SH:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].[C:13](OC(=O)C)(=[O:15])[CH3:14].Cl>C(O)(=O)C>[C:13]([S:1][C:2]1[C:10]([O:11][CH3:12])=[CH:9][CH:8]=[CH:7][C:3]=1[C:4]([OH:6])=[O:5])(=[O:15])[CH3:14]

Participants

5

Reactant 3

HCID 313Hydrochloric AcidHCID 7918Acetic AnhydrideHCID 166556102-Mercapto-3-methoxybenzoic acid

Product 1

HCID 204652112-Acetylthio-3-methoxybenzoic acid

Reagents, catalysts & solvents 1

HCID 176Acetic AcidSolvent

Procedure

A solution of 2-mercapto-3-methoxybenzoic acid (14.6 g, 79 mmol), acetic anhydride (9.7 g, 95 mmol) and glacial acetic acid (35 ml) was refluxed 15 minutes, then cooled and poured into dilute hydrochloric acid. The product was vacuum-filtered.

Workup

  1. temperaturecooled
  2. filtrationThe product was vacuum-filtered

Sources & evidence

ORD record
ord-30eff028606941938fb119fa7a2bed0d
Source dataset
uspto-grants-1984_04
Patent number
US04440941

Reaction notes

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