反应详情

温度

95 °C

33.4 g of 2-(2-fluorobenzyloxy)ethyl-2-(4-hydroxyphenoxy)propionate was dissolved in 120 ml of dimethylformamide, 15.2 g of potassium carbonate were added thereto, then the mixture was heated at 95° C. for one hour with stirring. 27.1 g of 4-trifluoromethyl chlorobenzene were added to the solution which was then heated to 95° to 100° C. for five hours. After cooling the reaction solution to room temperature, it was poured into ice-water, then extracted with toluene. The toluene layer was washed successively with 1% strength by weight sodium hydroxide solution and water, and was dried and filtered. The toluene was distilled off under reduced pressure, and further volatile by-products were removed at 100° C./0.1 mmHg. The end product of 2-(2-fluorobenzyloxy)ethyl-2-[4-(4-trifluoromethylphenoxy)phenoxy]propionate was obtained in a yield of 20.7 g. (nD20 1.5235)

1. temperaturewas then heated to 95° to 100° C. for five hours
2. temperatureAfter cooling the reaction solution to room temperature
3. extractionextracted with toluene
4. washThe toluene layer was washed successively with 1% strength by weight sodium hydroxide solution and water
5. customwas dried
6. filtrationfiltered
7. distillationThe toluene was distilled off under reduced pressure, and further volatile by-products
8. customwere removed at 100° C./0.1 mmHg