HRID3256

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID6422

未命名化合物

结构：CC(C)CC(NC(=O)c1cccnc1SSc1ncccc1C(=O)NC(CC(C)C)C(=O)OC(C)(C)C)C(=O)OC(C)(C)C

HCID76411778

未命名化合物

PRODUCTS

生成物

结构：CC(C)CC(NC(=O)c1cccnc1SSc1ncccc1C(=O)NC(CC(C)C)C(=O)O)C(=O)O

HCID85711217

未命名化合物

收率 77.4%

AUXILIARIES

试剂、催化剂与溶剂

溶剂HCID6344

Dichloromethane

CH2Cl2

溶剂HCID7519

Anisole

C7H8O

PROCEDURE

实验过程

The general method of Preparation 20 was followed using [S-(R*,R*)]-2-([2-[3-(1-tert-butoxycarbonyl-3-methyl-butylcarbamoyl)-pyridin-2-yldisulfanyl]pyridine-3-carbonyl]-amino)-4-methyl-pentanoic acid tert-butyl ester (1.9 g, 2.9 mmol) in 20 mL dichloromethane, anisole (1.5 mL), and 10 mL trifluoroacetic acid. The crude product was recrystallized from methanol/water to yield 1.2 g of the title compound.

WORKUP

后处理

customThe general method of Preparation 20
customThe crude product was recrystallized from methanol/water

来源与证据

来源类型: Open Reaction Database
ORD 记录: ord-1e43db34740c4500b323da3d86603bf8
来源数据集: uspto-grants-1998_03
DOI: 10.6084/m9.figshare.5104873.v1
专利: US05733921
来源说明: uspto-grants-1998_03

反应 SMILES

C([O:5][C:6](=[O:44])[CH:7]([NH:12][C:13]([C:15]1[C:16]([S:21][S:22][C:23]2[C:28]([C:29](=[O:43])[NH:30][CH:31]([C:36]([O:38]C(C)(C)C)=[O:37])[CH2:32][CH:33]([CH3:35])[CH3:34])=[CH:27][CH:26]=[CH:25][N:24]=2)=[N:17][CH:18]=[CH:19][CH:20]=1)=[O:14])[CH2:8][CH:9]([CH3:11])[CH3:10])(C)(C)C.FC(F)(F)C(O)=O>ClCCl.C1(OC)C=CC=CC=1>[C:36]([CH:31]([NH:30][C:29]([C:28]1[C:23]([S:22][S:21][C:16]2[C:15]([C:13]([NH:12][CH:7]([CH2:8][CH:9]([CH3:11])[CH3:10])[C:6]([OH:44])=[O:5])=[O:14])=[CH:20][CH:19]=[CH:18][N:17]=2)=[N:24][CH:25]=[CH:26][CH:27]=1)=[O:43])[CH2:32][CH:33]([CH3:35])[CH3:34])([OH:38])=[O:37]