Hydrochloric Acid → 2-(4-Methoxybenzyl)-2h-tetrazole-5-carboxylic acid

HRID 325742Notes

Reaction equation

HRID 325742 reaction equation
[CH3:1][O:2][C:3]1[CH:17]=[CH:16][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([C:13]([O-:15])=[O:14])=[N:9]2)=[CH:5][CH:4]=1.[K+].Cl>O>[CH3:1][O:2][C:3]1[CH:4]=[CH:5][C:6]([CH2:7][N:8]2[N:12]=[N:11][C:10]([C:13]([OH:15])=[O:14])=[N:9]2)=[CH:16][CH:17]=1

Participants

4

Reactant 2

HCID 313Hydrochloric AcidHCID 23677909HCID 23677909, compound

Product 1

HCID 135962442-(4-Methoxybenzyl)-2h-tetrazole-5-carboxylic acidYield 56.9%

Reagents, catalysts & solvents 1

HCID 962WaterSolvent

Procedure

Potassium 2-(4-methoxybenzyl)-2H-tetrazole-5-carboxylate (2.45 g) was dissolved in a minimum quantity of water and acidified to pH 1 by treatment with concentrated hydrochloric acid. The mixture was stirred for 3 hours, and then the solid was filtered off and washed with water to give 2-(4-methoxybenzyl)-2H-tetrazole-5-carboxylic acid (1.20 g), m.p. 146°-147° C. (with decomposition).

Workup

  1. filtrationthe solid was filtered off
  2. washwashed with water

Sources & evidence

ORD record
ord-92b9f2392cac41549c3f5f68dbc1dde4
Source dataset
uspto-grants-1984_04
Patent number
US04442115

Reaction notes

Loading…