m-Chloroperbenzoic acid → HCID 20426392, compound

HRID 326058Notes

Reaction equation

HRID 326058 reaction equation
[C:1]([N:11]1[CH2:16][CH2:15][N:14]([C:17]2[N:18]3[CH:30]=[CH:29][N:28]=[C:19]3[S:20][C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=3[N:23]=2)[CH2:13][CH2:12]1)([O:3][CH2:4][C:5]1[CH:10]=[CH:9][CH:8]=[CH:7][CH:6]=1)=[O:2].ClC1C=CC=C(C(OO)=[O:39])C=1>C(Cl)Cl.C(Cl)CCl>[C:1]([N:11]1[CH2:12][CH2:13][N:14]([C:17]2[N:18]3[CH:30]=[CH:29][N+:28]([O-:39])=[C:19]3[S:20][C:21]3[CH:27]=[CH:26][CH:25]=[CH:24][C:22]=3[N:23]=2)[CH2:15][CH2:16]1)([O:3][CH2:4][C:5]1[CH:6]=[CH:7][CH:8]=[CH:9][CH:10]=1)=[O:2]

Participants

5

Reactant 2

HCID 70297m-Chloroperbenzoic acidHCID 13364440HCID 13364440, compound

Product 1

HCID 20426392HCID 20426392, compound

Reagents, catalysts & solvents 2

HCID 111,2-DichloroethaneSolventHCID 6344DichloromethaneSolvent

Conditions

Temperature
0 °C

Procedure

To the solution of 0.5 g of 5-(4-carbobenzoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine in 5 ml of methylene chloride, cooled at 0° C., is added dropwise a solution of 0.26 g of m-chloroperbenzoic acid dissolved in 2 ml of ethylene chloride. The mixture is stirred at 0° C. for 1.5 hrs., the solids are filtered, and the filtrates are washed with 10% aqueous potassium carbonate and water, then dried over magnesium sulfate and evaporated to dryness to give 5-(4-carbobenzoxypiperazino)-imidazo[2,1-b][1,3,5]benzothiadiazepine 1-oxide.

Workup

  1. filtration, the solids are filtered
  2. washthe filtrates are washed with 10% aqueous potassium carbonate and water
  3. dry with materialdried over magnesium sulfate
  4. customevaporated to dryness

Sources & evidence

ORD record
ord-79a00ab95dea4e6c8d5e8afb8291d692
Source dataset
uspto-grants-1984_04
Patent number
US04444688

Reaction notes

Loading…