Caprolactam → HCID 12833262, compound

HRID 326070Notes

Reaction equation

HRID 326070 reaction equation
[H-].[Na+].[NH:3]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=[O:10].Br[CH2:12][CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]>>[CH2:12]([N:3]1[CH2:9][CH2:8][CH2:7][CH2:6][CH2:5][C:4]1=[O:10])[CH2:13][CH2:14][CH2:15][CH2:16][CH2:17][CH3:18]

Participants

4

Reactant 3

HCID 7768CaprolactamHCID 123691-BromoheptaneHCID 24758Sodium hydride2×

Product 1

HCID 12833262HCID 12833262, compoundYield 90%

Procedure

Following example 10, 10.2 g of 50% sodium hydride-mineral oil dispersion (5.1 g of NaH, 0.2125 M), 20 g (0.177 M) of azacycloheptan-2-one and 35.8 g (0.2 M) of 1-bromoheptane on 18 hr. reflux gave 33.5 g (90%) of colorless product; b.p. 155°-158°/0.5 mm.

Workup

  1. customon 18 hr
  2. temperaturereflux

Sources & evidence

ORD record
ord-26afcd6002fe42a9a3a409972f066a9e
Source dataset
uspto-grants-1984_04
Patent number
US04444762

Reaction notes

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