反应详情

温度

100 °C

A mixture of ethyl acetoacetate [VI-1] (260.6 g, 2.0 mol), toluene (300 g) and 1-bromo-5-chloropentane [V-1] (311.0 g, 1.68 mol) is heated to 80°-90° C. Thereto is added anhydrous potassium carbonate (300 g), and the temperature thereof is raised to 100° C. The mixture is reacted at the same temperature for 18 hours. After completion of the reaction, the mixture is filtered, and the toluene layer is washed with water, and concentrated under reduced pressure to give crude ethyl 7-chloro-2-(1-oxo-ethyl)-heptanoate [II-1] (403.8 g, content; 68.8 %, yield; 69.1 %).

1. temperatureis heated to 80°-90° C
2. customThe mixture is reacted at the same temperature for 18 hours
3. customAfter completion of the reaction
4. filtrationthe mixture is filtered
5. washthe toluene layer is washed with water
6. concentrationconcentrated under reduced pressure