反应详情

温度

100 °C

A mixture of 2 g (8 mmol) 1-Bromo-2-fluoro-4-trifluoromethyl-benzene and 2.13 g (25 mmol) piperazine in 2 ml N,N-dimethylacetamide was heated to 100° C. for 2 h and subsequently all volatiles were removed under vacuum. The residue was purified by flash column chromatography on silica eluting with DCM/methanol/1% NH3 aq. to yield 0.765 g (37%) of the title compound as colourless oil.

1. customsubsequently all volatiles were removed under vacuum
2. customThe residue was purified by flash column chromatography on silica eluting with DCM/methanol/1% NH3 aq.