HCID 10611577, compound → HCID 19735076, compound

HRID 326583Notes

Reaction equation

HRID 326583 reaction equation
[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:11][C:10]([CH3:13])([CH3:12])[N:9]=[C:8]([C:14]3[CH:19]=[CH:18]C=CN=3)[C:7]=2[CH:20]=1)#[N:2]>CN1CCCC1=O>[C:1]([C:3]1[CH:4]=[CH:5][C:6]2[O:11][C:10]([CH3:12])([CH3:13])[N:9]=[C:8]([CH:14]3[CH2:19][CH2:18][N:9]([CH3:8])[C:10]3=[O:11])[C:7]=2[CH:20]=1)#[N:2]

Participants

3

Reactant 1

HCID 10611577HCID 10611577, compound

Product 1

HCID 19735076HCID 19735076, compound

Reagents, catalysts & solvents 1

HCID 13387N-methyl-2-pyrrolidoneSolvent

Procedure

According to the same manner as that described in the preparation of Compound 1 in Example 1, 6-cyano-2,2-dimethyl-4-(1-methyl-2-oxopyrrolidin-3-yl)-2H-1,3-benzoxazine (Compound 15) was obtained except that N-methylpyrrolidone and a solution of 1.6M lithium diisopropylamide in a mixed solvent of tetrahydrofuran and hexane were used instead of 2-bromopyridine and the solution of 1.6M n-butyl lithium in hexane, respectively.

Sources & evidence

ORD record
ord-ad7ed4f510f94356acdce176b50b219d
Source dataset
uspto-grants-1993_12
Patent number
US05270308

Reaction notes

Loading…