反应详情

46.7 g (0.38 mole) of 2,6-dimethylphenol, 65.0 g (0.38 mole) of N-(2-chloroethyl)pyrrolidine hydrochloride, 210.1 g (1.52 mole) of potassium carbonate and 2 g of NaI in 300 ml of ethyl methyl ketone were refluxed for 48 h. The reaction mixture was concentrated under reduced pressure, the residue was partitioned between water and ether, the organic phase was separated off, washed with water and dried, and excess ethereal hydrogen chloride solution was added. The precipitated product was recrystallized from 10/1 ethyl acetate/isopropanol. 63 g of N-[2-(2,6-dimethylphenoxy)ethyl]pyrrolidine hydrochloride were obtained.

1. concentrationThe reaction mixture was concentrated under reduced pressure
2. customthe residue was partitioned between water and ether
3. customthe organic phase was separated off
4. washwashed with water
5. customdried
6. additionexcess ethereal hydrogen chloride solution was added
7. customThe precipitated product was recrystallized from 10/1 ethyl acetate/isopropanol