Diethyl Malonate → Diethyl 2-(2-methoxybenzylidene)malonate

HRID 326713Notes

Reaction equation

[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=O.[C:11]([O:19][CH2:20][CH3:21])(=[O:18])[CH2:12][C:13]([O:15][CH2:16][CH3:17])=[O:14]>>[CH3:1][O:2][C:3]1[CH:10]=[CH:9][CH:8]=[CH:7][C:4]=1[CH:5]=[C:12]([C:13]([O:15][CH2:16][CH3:17])=[O:14])[C:11]([O:19][CH2:20][CH3:21])=[O:18]

Participants

Reactant 2

HCID 7761Diethyl Malonate

HCID 86582-Methoxybenzaldehyde

Product 1

HCID 263261Diethyl 2-(2-methoxybenzylidene)malonate

Procedure

By Knoevenagel condensation of o-methoxybenzaldehyde with diethyl malonate, there was obtained diethyl o-methoxybenzylidenemalonate, boiling point 140° C./0.05 Torr.

Sources & evidence

ORD record: ord-8f59cda4f1f840aca984a649a434145b
Source dataset: uspto-grants-1993_12
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US05270313

Reaction notes

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