Pyrrolidine → 2-Chloro-5-(pyrrolidine-1-sulfonyl)benzoic acid

HRID 32674Notes

Reaction equation

HRID 32674 reaction equation
[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11](=[O:15])(=[O:14])[NH:12][CH3:13])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5].Cl[C:17]1[CH:25]=CC(S(O)=O)=C[C:18]=1C(O)=O.N1CCCC1>>[Cl:1][C:2]1[CH:10]=[CH:9][C:8]([S:11]([N:12]2[CH2:25][CH2:17][CH2:18][CH2:13]2)(=[O:15])=[O:14])=[CH:7][C:3]=1[C:4]([OH:6])=[O:5]

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 111724Benzoic acid, 2-chloro-5-[(methylamino)sulfonyl]-HCID 151129042-Chloro-5-sulfino-benzoic acid

Product 1

HCID 21198742-Chloro-5-(pyrrolidine-1-sulfonyl)benzoic acidYield 91%

Procedure

The title compound was synthesised according to the procedure described for 2-Chloro-5-methylsulfamoyl-benzoic acid from 2-Chloro-5-sulfino-benzoic acid and pyrrolidine and obtained in 91% yield. MS (m/e): 288.0 (MH−, 100%).

Workup

  1. customobtained in 91% yield

Sources & evidence

ORD record
ord-1e11387398a648819116aeffaedeb567
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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