5,6-Dichloro-3-oxoindan-1-carbonyl chloride → 4-(5,6-Dichloro-3-oxoindan-1-carbonyl)-3-(morpholinomethyl)morpholine hydrochloride

HRID 326742Notes

Reaction equation

HRID 326742 reaction equation
[O:1]1[CH2:6][CH2:5][N:4]([CH2:7][CH:8]2[CH2:13][O:12][CH2:11][CH2:10][NH:9]2)[CH2:3][CH2:2]1.[Cl:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][C:23]=1[Cl:24])[CH:20]([C:25](Cl)=[O:26])[CH2:19][C:18]2=[O:28]>C(N(CC)CC)C>[ClH:14].[Cl:14][C:15]1[CH:16]=[C:17]2[C:21](=[CH:22][C:23]=1[Cl:24])[CH:20]([C:25]([N:9]1[CH2:10][CH2:11][O:12][CH2:13][CH:8]1[CH2:7][N:4]1[CH2:5][CH2:6][O:1][CH2:2][CH2:3]1)=[O:26])[CH2:19][C:18]2=[O:28]

Participants

4

Reactant 2

HCID 151324075,6-Dichloro-3-oxoindan-1-carbonyl chlorideHCID 189150993-(Morpholinomethyl)morpholine

Product 1

HCID 189151274-(5,6-Dichloro-3-oxoindan-1-carbonyl)-3-(morpholinomethyl)morpholine hydrochlorideYield 73.9%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Example 24 was repeated, but using 1.25 g of 3-(morpholinomethyl)morpholine, 2.67 ml of triethylamine and 1.11 g of 5,6-dichloro-3-oxoindan-1-carbonyl chloride, to afford 0.7 g of the title compound, melting at 210°-216° C. (dec.).

Sources & evidence

ORD record
ord-88195629b6284286a46f571c9a3d93e8
Source dataset
uspto-grants-1993_12
Patent number
US05270327

Reaction notes

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