3-(Pyrrolidin-1-ylmethyl)thiomorpholine → HCID 178479631, compound

HRID 326748Notes

Reaction equation

HRID 326748 reaction equation
[N:1]1([CH2:6][CH:7]2[CH2:12][S:11][CH2:10][CH2:9][NH:8]2)[CH2:5][CH2:4][CH2:3][CH2:2]1.[O:13]=[C:14]1[C:18]2[S:19][CH:20]=[CH:21][C:17]=2[CH:16]([C:22]([Cl:24])=[O:23])[CH2:15]1>C(N(CC)CC)C>[ClH:24].[O:13]=[C:14]1[C:18]2[S:19][CH:20]=[CH:21][C:17]=2[CH:16]([C:22]([SH:11]2[CH2:10][CH2:9][NH:8][CH:7]([CH2:6][N:1]3[CH2:2][CH2:3][CH2:4][CH2:5]3)[CH2:12]2)=[O:23])[CH2:15]1

Participants

4

Reactant 2

HCID 157301473-(Pyrrolidin-1-ylmethyl)thiomorpholineHCID 189150194,5-dihydro-6-oxo-6H-cyclopenta[b]thiophene-4-carbonyl chloride

Product 1

HCID 178479631HCID 178479631, compoundYield 25.8%

Reagents, catalysts & solvents 1

HCID 8471TriethylamineSolvent

Procedure

The procedure described in Example 24 was repeated, but using 0.96 g of 3-(pyrrolidin-1-ylmethyl)thiomorpholine, 1.39 ml of triethylamine and 1.0 g of 4,5-dihydro-6 oxo-6H-cyclopenta[b]thiophene-4-carbonyl chloride, to afford 0.5 g of the title compound, melting at 204°-223° C.

Sources & evidence

ORD record
ord-6d5a8254218c489c908a79801091f2fb
Source dataset
uspto-grants-1993_12
Patent number
US05270327

Reaction notes

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