Pyrrolidine → 5-(Propane-2-sulfonyl)-2-pyrrolidin-1-yl-benzoic acid

HRID 32679Notes

Reaction equation

HRID 32679 reaction equation
CS(C1C=CC([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=C(C=1)C(O)=O)(=O)=O.Cl[C:20]1[CH:28]=[CH:27][C:26]([S:29]([CH:32]([CH3:34])[CH3:33])(=[O:31])=[O:30])=[CH:25][C:21]=1[C:22]([OH:24])=[O:23].N1CCCC1>>[CH3:33][CH:32]([S:29]([C:26]1[CH:27]=[CH:28][C:20]([N:14]2[CH2:18][CH2:17][CH2:16][CH2:15]2)=[C:21]([CH:25]=1)[C:22]([OH:24])=[O:23])(=[O:31])=[O:30])[CH3:34]

Participants

4

Reactant 3

HCID 31268PyrrolidineHCID 431409992-Chloro-5-(propane-2-sulfonyl)benzoic acidHCID 597934895-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid

Product 1

HCID 597936155-(Propane-2-sulfonyl)-2-pyrrolidin-1-yl-benzoic acidYield 72%

Procedure

The title compound was synthesised according to the procedure described for the synthesis of 5-Methanesulfonyl-2-pyrrolidin-1-yl-benzoic acid from 2-Chloro-5-(propane-2-sulfonyl)-benzoic acid and pyrrolidine and obtained in 72% yield. MS (m/e): 296.2 (MH−, 100%).

Workup

  1. customobtained in 72% yield

Sources & evidence

ORD record
ord-a8c0e4b2b4cb4225b0741446d7242d22
Source dataset
uspto-grants-2008_09
Patent number
US07427612B2

Reaction notes

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