Water → HCID 18952362, compound

HRID 326805Notes

Reaction equation

HRID 326805 reaction equation
Cl[C:2]1[C:11]2[C:6](=[C:7]([OH:13])[CH:8]=[CH:9][C:10]=2[Cl:12])[N:5]=[CH:4][N:3]=1.O.C([O-])(O)=O.[Na+].[CH:20]([OH:23])([CH3:22])[CH3:21]>>[Cl:12][C:10]1[CH:9]=[CH:8][C:7]([OH:13])=[C:6]2[C:11]=1[C:2]([O:23][CH:20]([CH3:22])[CH3:21])=[N:3][CH:4]=[N:5]2

Participants

5

Reactant 4

HCID 962WaterHCID 3776IsopropanolHCID 516892Sodium BicarbonateHCID 18952355HCID 18952355, compound

Product 1

HCID 18952362HCID 18952362, compound

Procedure

A mixture of 4,5-dichloro-8-quinazolinol (3.0 g, 13.95 mmol) in isopropanol is heated at reflux for 30 minutes, cooled to room temperature and filtered to obtain a solid. The solid is mixed with water and saturated NaHCO3 solution. The resultant mixture is filtered and the filter cake is washed with water and dried to give the title product as an off-white solid, 1.71 g, mp 126°-126.5° C.

Workup

  1. temperatureis heated
  2. temperatureat reflux for 30 minutes
  3. filtrationfiltered
  4. customto obtain a solid
  5. filtrationThe resultant mixture is filtered
  6. washthe filter cake is washed with water
  7. customdried

Sources & evidence

ORD record
ord-0130497050b143fabacd53d83708abd7
Source dataset
uspto-grants-1993_12
Patent number
US05270466

Reaction notes

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