HCID 14957731, compound → HCID 14957732, compound

HRID 327138Notes

Reaction equation

HRID 327138 reaction equation
[O:1]=[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([C:18]#[CH:19])[CH:16]=2)[C:11](=[O:20])[C:10]([CH3:22])([CH3:21])[CH:9]=1>C(OCC)(=O)C.[Pd]>[O:1]=[C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][N:3]1[C:8]1[C:17]2[C:12](=[CH:13][CH:14]=[C:15]([CH2:18][CH3:19])[CH:16]=2)[C:11](=[O:20])[C:10]([CH3:21])([CH3:22])[CH:9]=1

Participants

4

Reactant 1

HCID 14957731HCID 14957731, compound

Product 1

HCID 14957732HCID 14957732, compoundYield 0.1%

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 8857Ethyl AcetateSolvent

Procedure

To a solution of 0.15 g (0.51 mol) of the product obtained in example 50 in 9 mL ethyl acetate, were added 0.03 g of 5% Pd/C and the mixture was hydrogenated at atmospheric pressure for 2 h. After filtration, the solvent was removed, affording 0.110 g of the title compound of this example as a white solid (yield: 74%).

Workup

  1. filtrationAfter filtration
  2. customthe solvent was removed

Sources & evidence

ORD record
ord-d91ec63109f64e4d8a62cff91346d438
Source dataset
uspto-grants-1993_12
Patent number
US05272170

Reaction notes

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