反应详情

Suspend sodium hydride (47.2g of 56% in mineral oil, 1.10mol) in anhydrous tetrahydrofuran (1L). Place under a nitrogen atmosphere and add, by dropwise addition, trimethyl phosphonoacetate (209.4g, 1.15mol). Stir for 25 minutes and add a solution of 2-hydroxy-2-methyl-7-t-butyl-5-isopropyl-8-propyl-chroman-6-yl-acetate (0.5mol) in tetrahydrofuran (1L). Stir at room temperature for 18 hour then heat at reflux for 4 hours. Cool, evaporate the solvent in vacuo and purify by chromatography to give the title compound.

1. stirringStir at room temperature for 18 hour
2. temperaturethen heat
3. temperatureat reflux for 4 hours
4. temperatureCool
5. customevaporate the solvent in vacuo
6. custompurify by chromatography