1-(3,5-Difluorophenyl)pentan-1-ol → 1,3-Difluoro-5-(pent-1-en-1-yl)benzene

HRID 327371Notes

Reaction equation

HRID 327371 reaction equation
[P+3]=O.[F:3][C:4]1[CH:9]=[C:8]([CH:10](O)[CH2:11][CH2:12][CH2:13][CH3:14])[CH:7]=[C:6]([F:16])[CH:5]=1>CCCCC>[F:3][C:4]1[CH:9]=[C:8]([CH:10]=[CH:11][CH2:12][CH2:13][CH3:14])[CH:7]=[C:6]([F:16])[CH:5]=1

Participants

4

Reactant 2

HCID 225984431-(3,5-Difluorophenyl)pentan-1-olHCID 178526999HCID 178526999, compound

Product 1

HCID 536320701,3-Difluoro-5-(pent-1-en-1-yl)benzene

Reagents, catalysts & solvents 1

HCID 8003PentaneSolvent

Procedure

Phosphorus(v) oxide (64.5 g, 0.45 mol) is added to a stirred solution of compound 9A (35.0 g, 0.175 mol) in dry pentane (150 ml) at room temperature. The mixture is stirred at room temperature overnight (glc analysis revealed absence of starting material) and filtered.

Workup

  1. filtrationfiltered

Sources & evidence

ORD record
ord-82692c8c00af4fbca90d5793d6c3a70f
Source dataset
uspto-grants-1993_12
Patent number
US05273680

Reaction notes

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