Benzoyl Peroxide → HCID 19023690, compound

HRID 327411Notes

Reaction equation

HRID 327411 reaction equation
[CH3:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1.[Cl:12]N1C(=O)CCC1=O.C(OOC(=O)C1C=CC=CC=1)(=O)C1C=CC=CC=1>C(Cl)(Cl)(Cl)Cl>[Cl:12][CH2:1][C:2]1[CH:11]=[CH:10][C:9]2[C:4](=[N:5][CH:6]=[CH:7][CH:8]=2)[N:3]=1

Participants

5

Reactant 3

HCID 7187Benzoyl PeroxideHCID 31398ChlorosuccinimideHCID 740731,8-Naphthyridine, 2-methyl-

Product 1

HCID 19023690HCID 19023690, compound

Reagents, catalysts & solvents 1

HCID 5943Carbon TetrachlorideSolvent

Procedure

A solution of 2-methyl-1,8-naphthyridine (Chem. Pharm. Bull., 19, 1857 (1971)), N-chlorosuccinimide (1.1 equivalent), and a catalytic amount of benzoylperoxide in CCl4 were irradiated at reflux with a 225 watt lamp for 5 hours. After cooling, the solid was filtered and the filtrate evaporated to dryness. The crude residue was chromatographed to give the title product.

Workup

  1. temperatureat reflux with a 225 watt lamp for 5 hours
  2. temperatureAfter cooling
  3. filtrationthe solid was filtered
  4. customthe filtrate evaporated to dryness
  5. customThe crude residue was chromatographed

Sources & evidence

ORD record
ord-2c2073870aab46df98688f83d3a807a3
Source dataset
uspto-grants-1993_12
Patent number
US05273980

Reaction notes

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