Potassium Carbonate → HCID 54050485, compound

HRID 327421Notes

Reaction equation

HRID 327421 reaction equation
[SH:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1.Br[CH2:12][CH2:13][C:14]([F:18])=[C:15]([F:17])[F:16].C(=O)([O-])[O-].[K+].[K+]>CC(C)=O>[F:18][CH:14]([CH:15]([F:17])[F:16])[CH:13]=[CH:12][S:1][C:2]1[O:3][C:4]2[CH:10]=[CH:9][CH:8]=[CH:7][C:5]=2[N:6]=1

Participants

5

Reactant 3

HCID 11430Potassium CarbonateHCID 663334-Bromo-1,1,2-trifluorobut-1-eneHCID 1784182821,3-benzoxazole-2-thiol

Product 1

HCID 54050485HCID 54050485, compoundYield 103.2%

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

2-Mercaptobenzoxazole (2 g), 4-bromo-1,1,2-trifluorobut-1-ene (2.75 g) and potassium carbonate (1 g) were stirred together in 40 ml of acetone and heated to reflux. After 2 hours the reaction mixture was allowed to cool, filtered to remove insoluble potassium salts and the filterate was evaporated under reduced pressure to yield 3.54 g of a brown oil which was used in step b without purification.

Workup

  1. temperatureheated to reflux
  2. temperatureto cool
  3. filtrationfiltered
  4. customto remove insoluble potassium salts
  5. customthe filterate was evaporated under reduced pressure

Sources & evidence

ORD record
ord-9f6e829cf1764a139de2fb9ccefc6e2c
Source dataset
uspto-grants-1993_12
Patent number
US05273988

Reaction notes

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