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HRID327508

反应详情

EQUATION

反应方程式

HRID 327508 的结构方程式

REACTANTS

反应物

4
结构：CN1CCOCC1
HCID7972

4-Methylmorpholine

C5H11NO

2 次

结构：CC(C)(C)OC(=O)N1CCCC(C(=O)O)C1
HCID2735647

1-(tert-Butoxycarbonyl)piperidine-3-carboxylic acid

C11H19NO4

结构：COc1nnnc(OC)c1Cl
HCID12493616

未命名化合物

结构：Cc1ccc(S(=O)(=O)O)cc1.NCCC(=O)OCc1ccccc1
HCID13502100

4-Methylbenzene-1-sulfonic acid--benzyl beta-alaninate (1/1)

C17H21NO5S

PRODUCTS

生成物

1
结构：CC(C)(C)OC(=O)N1CCCC(C(=O)NCCC(=O)OCc2ccccc2)C1
HCID19926254

未命名化合物

AUXILIARIES

试剂、催化剂与溶剂

1
结构：C1CCOC1
溶剂HCID8028

Tetrahydrofuran

C4H8O

PROCEDURE

实验过程

rac-N-(t-butoxycarbonyl)piperidine-3-carboxylic acid (Can. J. Physiol. Pharmacol. 57, 1979, 763) in THF was activated with chlorodimethoxytriazine and N-methyl-morpholine and then coupled with β-alanine benzyl ester p-toluenesulphonate (J. Org. Chem. 17, 1952, 1564) and N-methylmorpholine to give rac-N-[[1-(t-butoxycarbonyl)-3-piperidinyl]-carbonyl]-β-alanine benzyl ester, m.p. 57°-59° C.