Triphenylphosphine → [(2-Cyclobutyl-4-thiazolyl)methyl]triphenylphosphonium chloride

HRID 327570Notes

Reaction equation

HRID 327570 reaction equation
[Cl:1][CH2:2][C:3]1[N:4]=[C:5]([CH:8]2[CH2:11][CH2:10][CH2:9]2)[S:6][CH:7]=1.[C:12]1([P:18]([C:25]2[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=2)[C:19]2[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=2)[CH:17]=[CH:16][CH:15]=[CH:14][CH:13]=1>C1(C)C=CC=CC=1>[Cl-:1].[CH:8]1([C:5]2[S:6][CH:7]=[C:3]([CH2:2][P+:18]([C:19]3[CH:20]=[CH:21][CH:22]=[CH:23][CH:24]=3)([C:25]3[CH:30]=[CH:29][CH:28]=[CH:27][CH:26]=3)[C:12]3[CH:13]=[CH:14][CH:15]=[CH:16][CH:17]=3)[N:4]=2)[CH2:11][CH2:10][CH2:9]1

Participants

4

Reactant 2

HCID 11776TriphenylphosphineHCID 187590944-Chloromethyl-2-cyclobutyl-thiazole

Product 1

HCID 20084325[(2-Cyclobutyl-4-thiazolyl)methyl]triphenylphosphonium chlorideYield 41.7%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

A mixture of 4.8 g of 4-chloromethyl-2-cyclobutyl-thiazole, 7.0 g of triphenylphosphine and 125 ml of toluene was heated to reflux for 16 hr and then cooled to room temperature. The mixture was then filtered to yield 4.8 g of [(2-cyclobutyl-4-thiazolyl)methyl]triphenylphosphonium chloride.

Workup

  1. temperaturewas heated
  2. temperatureto reflux for 16 hr
  3. filtrationThe mixture was then filtered

Sources & evidence

ORD record
ord-73cd87565a8d4de0b4d3f8e685eaf428
Source dataset
uspto-grants-1993_12
Patent number
US05273986

Reaction notes

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