反应详情

A solution of (2-Iodo-5-methanesulfonyl-phenyl)-[4-(4-trifluoromethyl-phenyl)-piperazin-1-yl]-methanone (compound CK, 0.05 g, 0.09 mmol) and of cyclobutylamine (0.1 ml) in dimethylacetamide was heated in a microwave oven (180 deg) for 10 min before being concentrated in vacuo. The residue was disolve in ethyl acetate, washed with water dried over sodiumsulfate, filtered and concentrated. The residue was purified by column chromatography (SiO2, 5 g, Heptane/EtOAc 0-50%) to give the title compound as a white foam (24 mg, 54%). MS (m/e): 482.5 (M+H+, 100%).

1. concentrationbefore being concentrated in vacuo
2. washwashed with water
3. dry with materialdried over sodiumsulfate
4. filtrationfiltered
5. concentrationconcentrated
6. customThe residue was purified by column chromatography (SiO2, 5 g, Heptane/EtOAc 0-50%)