Benzene → 2-Fluorophenyl sulfamate

HRID 327739Notes

Reaction equation

HRID 327739 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[OH:8].Cl[S:10]([N:13]=C=O)(=[O:12])=[O:11].C1C=CC=CC=1>C1(C)C=CC=CC=1>[F:1][C:2]1[CH:7]=[CH:6][CH:5]=[CH:4][C:3]=1[O:8][S:10](=[O:12])(=[O:11])[NH2:13]

Participants

5

Reactant 3

HCID 241BenzeneHCID 97072-FluorophenolHCID 70918Chlorosulfonyl isocyanate

Product 1

HCID 539088522-Fluorophenyl sulfamateYield 38.2%

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Procedure

This compound was prepared according to the procedure of Example 56. A mixture of 11.2 g (0.1 mole) of 2-fluorophenol and 9.1 ml (14.8 g, 0.105 mole) of chlorosulfonyl isocyanate in 50 ml of toluene gave 7.3 g (38%) of the title compound as a white solid, mp 63°-64° (benzene).

Workup

  1. customThis compound was prepared

Sources & evidence

ORD record
ord-e98fb441880b41db928d4d12bffe22b3
Source dataset
uspto-grants-1993_12
Patent number
US05273993

Reaction notes

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