Benzoyl chloride → HCID 22751148, compound

HRID 328067Notes

Reaction equation

HRID 328067 reaction equation
[NH:1]([C:3]1[N:4]=[N:5][C:6]([N:10]2[CH2:15][CH2:14][O:13][CH2:12][CH2:11]2)=[CH:7][C:8]=1[CH3:9])[NH2:2].C(N(CC)CC)C.[C:23](Cl)(=O)[C:24]1[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=1>O1CCOCC1>[CH3:9][C:8]1[C:3]2[N:4]([C:23]([C:24]3[CH:29]=[CH:28][CH:27]=[CH:26][CH:25]=3)=[N:2][N:1]=2)[N:5]=[C:6]([N:10]2[CH2:11][CH2:12][O:13][CH2:14][CH2:15]2)[CH:7]=1

Participants

5

Reactant 3

HCID 7412Benzoyl chlorideHCID 8471TriethylamineHCID 2161094-(6-Hydrazinyl-5-methyl-3-pyridazinyl)morpholine

Product 1

HCID 22751148HCID 22751148, compound

Reagents, catalysts & solvents 1

HCID 312751,4-DioxaneSolvent

Procedure

1.48 Grams of 3-hydrazino-4-methyl-6-morpholinopyridazine and 1.8 grams of triethylamine are dissolved in 200 milliliters of dioxane. 3.5 Grams benzoyl chloride are added to the resulting mixture, and the mixture is heated at the boiling temperature under reflux for 3 hours. The mixture is evaporated to dryness, and the 8-methyl-6- -morpholino-3-phenyl-s-triazolo[4,3-b]pyridazine product is obtained as a residue. The product is washed with water, recrystallized from ethanol and found to melt at a temperature of 271°-273° C. 3.6 Grams of the product are obtained.

Workup

  1. temperaturethe mixture is heated at the boiling temperature
  2. temperatureunder reflux for 3 hours
  3. customThe mixture is evaporated to dryness

Sources & evidence

ORD record
ord-ddcdc3c7971b4ec58bff1b26d7ca6e40
Source dataset
uspto-grants-1977_04
Patent number
US04016162

Reaction notes

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